Publications Roukos since 2019

2024

Longo GMC, Sayols S, Kotini AG, Heinen S, Möckel MM, Beli P, Roukos V (2024) Linking CRISPR-Cas9 double-strand break profiles to gene editing precision with BreakTag.Nat Biotechnol., doi: 10.1038/s41587-024-02238-8 Link

Zhang N, Harbers L, Simonetti M, Diekmann C, Verron Q, Berrino E, Bellomo SE, Longo GMC, Ratz M, Schultz N, Tarish F, Su P, Han B, Wang W, Onorato S, Grassini D, Ballarino R, Giordano S, Yang Q, Sapino A, Frisén J, Alkass K, Druid H, Roukos V, Helleday T, Marchiò C, Bienko M, Crosetto N (2024) High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue. Nat Commun., doi: 10.1038/s41467-024-47664-z Link

2022

Petropoulos M, Champeris Tsaniras S, Nikou S, Maxouri S, Dionellis VS, Kalogeropoulou A, Karamichali A, Ioannidis K, Danalatos I-R, Obst M, Naumann R, Delinasios GJ, Gorgoulis VG, Roukos V, Anastassiadis K, Halazonetis TD, Bravou V, Lygerou Z and Taraviras S (2022) Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage.J Pathol, doi: 10.1002/path.6017 Link

Mosler T, Baymaz HI, Gräf JF, Mikicic I, Blattner G, Bartlett E, Ostermaier M, Piccinno R, Yang J, Voigt A, Gatti M, Pellegrino S , Altmeyer M,  Luck K, Ahel I, Roukos V , Beli P (2022) PARP1 proximity reveals interaction partners at stressedreplication forksy.Nucleic Acids Re, doi: 10.1093/nar/gkac948 Link

Tsaridou S, Velimezi G, Willenbrock F, Chatzifrangkeskou M, Elsayed W, Panagopoulos A, Karamitros D, Gorgoulis V, Lygerou Z, Roukos V, O’Neill E and Pefani DE (2022)  53BP1 ‐mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling . EMBO Rep, doi: 10.15252/embr.202154483 Link

Abu-Libdeh B, Jhujh SS, Dhar S, Sommers JA, Datta A, Longo GMC, Grange LJ, Reynolds JJ, Cooke SL, McNee GS, Hollingworth R, Woodward BL, Ganesh AN, Smerdon SJ, Nicolae CM, Durlacher-Betzer K, Molho-Pessach V, Abu-Libdeh A, Meiner V, Moldovan G-L, Roukos V, Harel T, Brosh Jr. RM and Stewart GS (2022) RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. J Clin Invest, doi: 10.1172/JCI147301 Link

2021

Mosler T, Conte F, Longo GMC, Mikicic I, Kreim N, Möckel MM, Petrosino G, Flach J, Barau J, Luke B, Roukos V and Beli P (2021) R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nat Commun, doi: 10.1038/s41467-021-27530-y Link

Papantonis A and Roukos V (2021) Cohesin puts a break on distal homology hunt. Nat Cell Biol, doi: 10.1038/s41556-021-00791-x Link

Zhang S, Übelmesser N, Josipovic N, Forte G, Slotman JA, Chiang M, Gothe HJ, Gusmao EG, Becker C, Altmüller J, Houtsmuller AB, Roukos V, Wendt KS, Marenduzzo D and Papantonis A (2021) RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis. Sci Adv, doi: 10.1126/sciadv.abg8205 Link

Longo GMC and Roukos V (2021) Territories or spaghetti? Chromosome organization exposed. Nat Rev Mol Cell Biol, doi: 10.1038/s41580-021-00372-8 Link

2020

Bouwman BAM, Agostini F, Garnerone S, Petrosino G, Gothe HJ, Sayols S, Moor AE, Itzkovitz S, Bienko M, Roukos V and Crosetto N (2020) Genome-wide detection of DNA double-strand breaks by in-suspension BLISS. Nat Protoc, doi: 10.1038/s41596-020-0397-3 Link

2019

Lucic B, Chen H-C, Kuzman M, Zorita E, Wegner J, Minneker V, Wang W, Fronza R, Laufs S, Schmidt M, Stadhouders R, Roukos V, Vlahovicek K, Filion GJ and Lusic M (2019) Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration.Nat Commun, doi: 10.1038/s41467-019-12046-3 Link

Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner E-M, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A, Crosetto N and Roukos V (2019) Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.Mol Cell, doi: 10.1016/j.molcel.2019.05.015 Link

Piccinno R, Minneker V and Roukos V (2019) 53BP1—DNA repair enters a new liquid phase. EMBO J, doi: 10.15252/embj.2019102871 Link