2024
Longo GMC, Sayols S, Stefanova ME, Xie T, Elsayed W, Panagi A, Stavridou AI, Petrosino G, Ing-Simmons E, Melo US, Gothe HJ, Vaquerizas JM, Kotini AG, Papantonis A, Mundlos S, Roukos V (2024) Type II topoisomerases shape multi-scale 3D chromatin folding in regions of positive supercoils. Mol Cell., doi: 10.1016/j.molcel.2024.10.007 Link
Longo GMC, Sayols S, Kotini AG, Heinen S, Möckel MM, Beli P, Roukos V (2024) Linking CRISPR-Cas9 double-strand break profiles to gene editing precision with BreakTag.Nat Biotechnol., doi: 10.1038/s41587-024-02238-8 Link
Zhang N, Harbers L, Simonetti M, Diekmann C, Verron Q, Berrino E, Bellomo SE, Longo GMC, Ratz M, Schultz N, Tarish F, Su P, Han B, Wang W, Onorato S, Grassini D, Ballarino R, Giordano S, Yang Q, Sapino A, Frisén J, Alkass K, Druid H, Roukos V, Helleday T, Marchiò C, Bienko M, Crosetto N (2024) High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue. Nat Commun., doi: 10.1038/s41467-024-47664-z Link
2022
Petropoulos M, Champeris Tsaniras S, Nikou S, Maxouri S, Dionellis VS, Kalogeropoulou A, Karamichali A, Ioannidis K, Danalatos I-R, Obst M, Naumann R, Delinasios GJ, Gorgoulis VG, Roukos V, Anastassiadis K, Halazonetis TD, Bravou V, Lygerou Z and Taraviras S (2022) Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage.J Pathol, doi: 10.1002/path.6017 Link
Mosler T, Baymaz HI, Gräf JF, Mikicic I, Blattner G, Bartlett E, Ostermaier M, Piccinno R, Yang J, Voigt A, Gatti M, Pellegrino S , Altmeyer M, Luck K, Ahel I, Roukos V , Beli P (2022) PARP1 proximity reveals interaction partners at stressedreplication forksy.Nucleic Acids Re, doi: 10.1093/nar/gkac948 Link
Tsaridou S, Velimezi G, Willenbrock F, Chatzifrangkeskou M, Elsayed W, Panagopoulos A, Karamitros D, Gorgoulis V, Lygerou Z, Roukos V, O’Neill E and Pefani DE (2022) 53BP1 ‐mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling . EMBO Rep, doi: 10.15252/embr.202154483 Link
Abu-Libdeh B, Jhujh SS, Dhar S, Sommers JA, Datta A, Longo GMC, Grange LJ, Reynolds JJ, Cooke SL, McNee GS, Hollingworth R, Woodward BL, Ganesh AN, Smerdon SJ, Nicolae CM, Durlacher-Betzer K, Molho-Pessach V, Abu-Libdeh A, Meiner V, Moldovan G-L, Roukos V, Harel T, Brosh Jr. RM and Stewart GS (2022) RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. J Clin Invest, doi: 10.1172/JCI147301 Link
2021
Mosler T, Conte F, Longo GMC, Mikicic I, Kreim N, Möckel MM, Petrosino G, Flach J, Barau J, Luke B, Roukos V and Beli P (2021) R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nat Commun, doi: 10.1038/s41467-021-27530-y Link
Papantonis A and Roukos V (2021) Cohesin puts a break on distal homology hunt. Nat Cell Biol, doi: 10.1038/s41556-021-00791-x Link
Zhang S, Übelmesser N, Josipovic N, Forte G, Slotman JA, Chiang M, Gothe HJ, Gusmao EG, Becker C, Altmüller J, Houtsmuller AB, Roukos V, Wendt KS, Marenduzzo D and Papantonis A (2021) RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis. Sci Adv, doi: 10.1126/sciadv.abg8205 Link
Longo GMC and Roukos V (2021) Territories or spaghetti? Chromosome organization exposed. Nat Rev Mol Cell Biol, doi: 10.1038/s41580-021-00372-8 Link
2020
Bouwman BAM, Agostini F, Garnerone S, Petrosino G, Gothe HJ, Sayols S, Moor AE, Itzkovitz S, Bienko M, Roukos V and Crosetto N (2020) Genome-wide detection of DNA double-strand breaks by in-suspension BLISS. Nat Protoc, doi: 10.1038/s41596-020-0397-3 Link
2019
Lucic B, Chen H-C, Kuzman M, Zorita E, Wegner J, Minneker V, Wang W, Fronza R, Laufs S, Schmidt M, Stadhouders R, Roukos V, Vlahovicek K, Filion GJ and Lusic M (2019) Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration.Nat Commun, doi: 10.1038/s41467-019-12046-3 Link
Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner E-M, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A, Crosetto N and Roukos V (2019) Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.Mol Cell, doi: 10.1016/j.molcel.2019.05.015 Link
Piccinno R, Minneker V and Roukos V (2019) 53BP1—DNA repair enters a new liquid phase. EMBO J, doi: 10.15252/embj.2019102871 Link