This project aims to uncover interdependencies between the nature of senescence-maintaining non-repaired DNA lesions and the complexes involved in their signalling. Thus, we will analyse the localization and composition of DNA-SCARS. The expected results will reveal whether DNA lesions in specific genomic regions are more prone to be converted into non-repairable DNA lesions. In addition, the impact of the SCARS and p21CIP1 on senescence maintenance will be analysed using an auxin-inducible degron 2 system, targeting 53BP1, H2AX, or p21CIP1. The expected results will reveal to which degree these components are responsible for senescence maintenance in response to different types of genotoxic stress.
Prof. Dr Markus Christmann
University Medical Center Mainz
Institute of Toxicology
Obere Zahlbacher Strasse 67
Webpage Christmann lab
Publications since 2019
Project summary first funding period (2019-2022)