Project 11 - Oliver Krämer

The precise control of DNA replication and the correction of DNA replication errors by distinct DNA repair mechanisms is the base for life and a salient feature of homeostasis. Our project will elucidate how the control of site-specific protein phosphorylation by the PP2A-PR130 complex and the regulation of protein acetylation by the epigenetic erasers HDAC1, HDAC2, and HDAC3 modulates DNA replication timing, DNA repair, and the impact of compromised DNA replication fork progression on cell fate decisions.