Structural mechanism of MRN-ATM in DSB signaling and processing
This project aims at elucidating how DNA double-strand breaks are detected, signalled and processed by the Mre11-Rad50-Nbs1-ATM axis. To achieve this, we will use a combination of cryo-EM, biochemistry and cell-based studies. In particular, we will functionally and structurally dissect catalytic and scaffolding roles of MRN in order to provide molecular mechanisms for its poorly understood, pleiotropic functions in DSB repair and chromatin architecture.
Prof. Dr Karl-Peter Hopfner
Gene Center and Department of Biochemistry
Webpage Hopfner lab
Publications since 2019
Project summary first funding period (2019-2022)