Publications since 2019

Ren M, Gut F, Fan Y, Ma J, Shan X, Yikilmazsoy A, Likhodeeva M, Hopfner KP, Zhou C (2024) Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles.Nat Commun., doi: 10.1038/s41467-024-53811-3 Link

Karl LA, Galanti L, Bantele SC, Metzner F, Šafarić B, Rajappa L, Foster B, Pires VB, Bansal P, Chacin E, Basquin J, Duderstadt KE, Kurat CF, Bartke T, Hopfner KP and Pfander B (2023) A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler. Life Sci alliance, doi: 10.26508/lsa.202201790 Link

Zhang M, Jungblut A, Kunert F, Hauptmann L, Kolesnikova O, Metzner F, Weis F, DiMaio F, Hopfner K-P and Eustermann S (2023) Hexasome-INO80 complex reveals structural basis of non-canonical nucleosome remodeling. Science (80- ), doi: 10.1126/science.adf6287 Link

Woike S, Eustermann S, Jung J, Wenzl SJ, Hagemann G, Bartho J, Lammens K, Butryn A, Herzog F and Hopfner K-P (2023) Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat Struct Mol Biol, doi: 10.1038/s41594-023-00966-0 Link

Hopfner K-P (2023) Mre11–Rad50: the DNA end game. Biochem Soc Trans, doi: 10.1042/BST20220754 Link

Rotheneder M, Stakyte K, van de Logt E, Bartho JD, Lammens K, Fan Y, Alt A, Kessler B, Jung C, Roos WP, Steigenberger B and Hopfner K-P (2022) Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol Cell, doi: 10.1016/j.molcel.2022.12.003 Link

Kunert F, Metzner FJ, Jung J, Höpfler M, Woike S, Schall K, Kostrewa D, Moldt M, Chen JX, Bantele S, Pfander B, Eustermann S and Hopfner KP (2022) Structural mechanism of extranucleosomal DNA readout by the INO80 complex. Sci Adv, doi: 10.1126/sciadv.add3189 Link

Khatamzas E, Antwerpen MH, Rehn A, Graf A, Hellmuth JC, Hollaus A, Mohr A-W, Gaitzsch E, Weiglein T, Georgi E, Scherer C, Stecher S-S, Gruetzner S, Blum H, Krebs S, Reischer A, Leutbecher A, Subklewe M, Dick A, Zange S, Girl P, Müller K, Weigert O, Hopfner K-P, Stemmler H-J, von Bergwelt-Baildon M, Keppler OT, Wölfel R, Muenchhoff M and Moosmann A (2022) Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection. Nat Commun, doi: 10.1038/s41467-022-32772-5 Link

Metzner FJ, Wenzl SJ, Kugler M, Krebs S, Hopfner K-P and Lammens K (2022) Mechanistic understanding of human SLFN11. Nat Commun, doi: 10.1038/s41467-022-33123-0 Link

Hohle MM, Lammens K, Gut F, Wang B, Kahler S, Kugler K, Till M, Beckmann R, Hopfner K-P and Jung C (2022) Ice thickness monitoring for cryo-EM grids by interferometry imaging. Sci Rep, doi: 10.1038/s41598-022-16978-7 Link

Kessler N, Viehmann SF, Krollmann C, Mai K, Kirschner KM, Luksch H, Kotagiri P, Böhner AMC, Huugen D, de Oliveira Mann CC, Otten S, Weiss SAI, Zillinger T, Dobrikova K, Jenne DE, Behrendt R, Ablasser A, Bartok E, Hartmann G, Hopfner K-P, Lyons PA, Boor P, Rösen-Wolff A, Teichmann LL, Heeringa P, Kurts C and Garbi N (2022) Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. J Exp Med, doi: 10.1084/jem.20220759 Link

Gut F, Käshammer L, Lammens K, Bartho JD, Boggusch A-M, van de Logt E, Kessler B and Hopfner K-P (2022) Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50, doi: 10.1016/j.molcel.2022.07.019 Link

Stazzoni S, Böhmer DFR, Hernichel F, Özdemir D, Pappa A, Drexler D, Bauernfried S, Witte G, Wagner M, Veth S, Hopfner K-P, Hornung V, König LM and Carell T (2022) Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists. Angewandte Chemie Int Ed, doi: 10.1002/anie.202207175 Link

Veth S, Fuchs A, Özdemir D, Dialer C, Drexler DJ, Knechtel F, Witte G, Hopfner K-P, Carell T and Ploetz E (2022) Chemical synthesis of the fluorescent, cyclic dinucleotides cthGAMP. ChemBioChem, doi: 10.1002/cbic.202200005 Link

Metzner FJ, Huber E, Hopfner K-P and Lammens K (2022) Structural and biochemical characterization of human Schlafen 5. Nucleic Acids Res, doi: 10.1093/nar/gkab1278 Link

Tahk S, Vick B, Hiller B, Schmitt S, Marcinek A, Perini ED, Leutbecher A, Augsberger C, Reischer A, Tast B, Humpe A, Jeremias I, Subklewe M, Fenn NC and Hopfner K-P (2021) SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells. J Hematol Oncol, doi: 10.1186/s13045-021-01163-6 Link

Stakyte K, Rotheneder M, Lammens K, Bartho JD, Grädler U, Fuchß T, Pehl U, Alt A, van de Logt E and Hopfner KP (2021) Molecular basis of human ATM kinase inhibition. Nat Struct Mol Biol, doi: 10.1038/s41594-021-00654-x Link

Bandera AM, Bartho J, Lammens K, Drexler DJ, Kleinschwärzer J, Hopfner K-P and Witte G (2021) BusR senses bipartite DNA binding motifs by a unique molecular ruler architecture. Nucleic Acids Res, doi: 10.1093/nar/gkab736 Link

Boehmer DFR, Formisano S, de Oliveira Mann CC, Mueller SA, Kluge M, Metzger P, Rohlfs M, Hörth C, Kocheise L, Lichtenthaler SF, Hopfner K-P, Endres S, Rothenfusser S, Friedel CC, Duewell P, Schnurr M and Koenig LM (2021) OAS1/RNase L executes RIG-I ligand–dependent tumor cell apoptosis. Sci Immunol, doi: 10.1126/sciimmunol.abe2550 Link

Oliveira Mann CC and Hopfner K (2021) Nuclear cGAS: guard or prisoner?EMBO J, doi: 10.15252/embj.2021108293 Link

Oberbeckmann E, Niebauer V, Watanabe S, Farnung L, Moldt M, Schmid A, Cramer P, Peterson CL, Eustermann S, Hopfner K-P and Korber P (2021) Ruler elements in chromatin remodelers set nucleosome array spacing and phasing. Nat Commun, doi: 10.1038/s41467-021-23015-0 Link

Oberbeckmann E, Krietenstein N, Niebauer V, Wang Y, Schall K, Moldt M, Straub T, Rohs R, Hopfner K-P, Korber P and Eustermann S (2021) Genome information processing by the INO80 chromatin remodeler positions nucleosomes. Nat Commun, doi: 10.1038/s41467-021-23016-z Link

Apel F, Andreeva L, Knackstedt LS, Streeck R, Frese CK, Goosmann C, Hopfner KP and Zychlinsky A (2021) The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps. Sci Signal, doi: 10.1126/scisignal.aax7942 Link

Benmebarek M-R, Cadilha BL, Herrmann M, Lesch S, Schmitt S, Stoiber S, Darwich A, Augsberger C, Brauchle B, Rohrbacher L, Oner A, Seifert M, Schwerdtfeger M, Gottschlich A, Rataj F, Fenn NC, Klein C, Subklewe M, Endres S, Hopfner K-P and Kobold S (2021) A modular and controllable T cell therapy platform for acute myeloid leukemia. Leukemia, doi: 10.1038/s41375-020-01109-w Link

Schmitt S, Tahk S, Lohner A, Hänel G, Maiser A, Hauke M, Patel L, Rothe M, Josenhans C, Leonhardt H, Griffioen M, Deiser K, Fenn NC, Hopfner K-P and Subklewe M (2020) Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells. Front Immunol, doi: 10.3389/fimmu.2020.602802 Link

Basu A, Bobrovnikov DG, Qureshi Z, Kayikcioglu T, Ngo TTM, Ranjan A, Eustermann S, Cieza B, Morgan MT, Hejna M, Rube HT, Hopfner K-P, Wolberger C, Song JS and Ha T (2020) Measuring DNA mechanics on the genome scale. Nature, doi: 10.1038/s41586-020-03052-3 Link

Jansma M and Hopfner K-P (2020) Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs. Prog Biophys Mol Biol, doi: 10.1016/j.pbiomolbio.2020.10.009 Link

Michalski S, de Oliveira Mann CC, Stafford C, Witte G, Bartho J, Lammens K, Hornung V and Hopfner K-P (2020) Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature, doi: 10.1038/s41586-020-2748-0 Link

Jungblut A, Hopfner K-P and Eustermann S (2020) Megadalton chromatin remodelers: common principles for versatile functions.Curr Opin Struct Biol, doi: 10.1016/j.sbi.2020.06.024 Link

Hopfner K-P and Hornung V (2020) Molecular mechanisms and cellular functions of cGAS–STING signalling. Nat Rev Mol Cell Biol, doi: 10.1038/s41580-020-0244-x Link

Bararia D, Hildebrand JA, Stolz S, Haebe S, Alig S, Trevisani CP, Osorio-Barrios F, Bartoschek MD, Mentz M, Pastore A, Gaitzsch E, Heide M, Jurinovic V, Rautter K, Gunawardana J, Sabdia MB, Szczepanowski M, Richter J, Klapper W, Louissaint A, Ludwig C, Bultmann S, Leonhardt H, Eustermann S, Hopfner K-P, Hiddemann W, von Bergwelt-Baildon M, Steidl C, Kridel R, Tobin JWD, Gandhi MK, Weinstock DM, Schmidt-Supprian M, Sárosi MB, Rudelius M, Passerini V, Mautner J and Weigert O (2020) Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma. Cell Rep, doi: 10.1016/j.celrep.2020.107522 Link

Jansma M, Linke-Winnebeck C, Eustermann S, Lammens K, Kostrewa D, Stakyte K, Litz C, Kessler B and Hopfner K-P (2019) Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, doi: 10.1016/j.str.2019.10.013 Link

Sustmann C, Dickopf S, Regula JT, Kettenberger H, Mølhøj M, Gassner C, Weininger D, Fenn S, Manigold T, Kling L, Künkele K-P, Schwaiger M, Bossenmaier B, Griese JJ, Hopfner K-P, Graff-Meyer A, Stahlberg H, Ringler P, Lauer ME, Brinkmann U, Schaefer W and Klein C (2019) DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity.MAbs, doi: 10.1080/19420862.2019.1661736 Link

Käshammer L, Saathoff J-H, Lammens K, Gut F, Bartho J, Alt A, Kessler B and Hopfner K-P (2019) Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. Mol Cell, doi: 10.1016/j.molcel.2019.07.035 Link

Dialer CR, Stazzoni S, Drexler DJ, Müller FM, Veth S, Pichler A, Okamura H, Witte G, Hopfner KP and Carell T (2019) A Click-Chemistry Linked 2'3'-cGAMP Analogue. Chem - A Eur J, doi: 10.1002/chem.201805409 Link