Project 19 - Thomas Hofmann

Deconstructing the role of HIPK2 in DNA repair and genome stability

This project aims at clarifying mechanisms and pathways influencing DNA double-strand break repair pathway choice and at understanding how these are interlinked to cell fate choice upon DNA damage. We have identified novel signalling modules that impact on DSB repair upon DNA damage. These modules will be mechanistically and functionally analysed in the context of endogenous lesions with a focus on the replicative stress response.


Project 19 - Thomas Hofmann

Prof. Dr Thomas Hofmann

University Medical Center Mainz
Institute of Toxicology
Obere Zahlbacher Strasse 67
55131 Mainz


Webpage Hofmann lab
Publications since 2019
Project summary first funding period (2019-2022)