2024
Schmidt A, Allmann S, Schwarzenbach C, Snyder P, Chen J, Nagel G, Schöneis A, Rasenberger B, Beli P, Loewer A, Hofmann T, Tomicic M, Christmann M (2024) The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence.Nucleic Acids Research, doi: 10.1093/nar/gkae426 Link
Carnie C, Götz M, Palma-Chaundler C, Weickert P, Wanders A, Serrano-Benitez A, Li H, Gupta V, Awwad S, Blum C, Sczaniecka-Clift M, Cordes J, Zagnoli-Vieira G, D´Alessandro G, Richards S, Gueorguieva N, Lam S, Beli P, Stingele J, Jackson S (2024) Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS. EMBO J., doi: 10.1038/s44318-024-00108-2 Link
Longo GMC, Sayols S, Kotini AG, Heinen S, Möckel MM, Beli P, Roukos V (2024) Linking CRISPR-Cas9 double-strand break profiles to gene editing precision with BreakTag.Nat Biotechnol., doi: 10.1038/s41587-024-02238-8 Link
2023
D’Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G and Jackson SP (2023) RAD54L2 counters TOP2-DNA adducts to promote genome stability. Sci Adv, doi: 10.1126/sciadv.adl2108 Link
Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R and Stingele J (2023) RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks. Mol Cell, doi: 10.1016/j.molcel.2023.10.012 Link
Suryo Rahmanto A, Blum CJ, Scalera C, Heidelberger JB, Mesitov M, Horn-Ghetko D, Gräf JF, Mikicic I, Hobrecht R, Orekhova A, Ostermaier M, Ebersberger S, Möckel MM, Krapoth N, Da Silva Fernandes N, Mizi A, Zhu Y, Chen J-X, Choudhary C, Papantonis A, Ulrich HD, Schulman BA, König J and Beli P (2023) K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution. Mol Cell, doi: 10.1016/j.molcel.2023.10.011 Link
Oliveira CAB, Isaakova E, Beli P and Xirodimas DP (2023) A Mass Spectrometry-Based Strategy for Mapping Modification Sites for the Ubiquitin-Like Modifier NEDD8. doi: 10.1007/978-1-0716-2859-1_10 Link
Stier A, Gilberto S, Mohamed WI, Royall LN, Helenius J, Mikicic I, Sajic T, Beli P, Müller DJ, Jessberger S and Peter M (2023) The CUL4B ‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs. EMBO J, doi: 10.15252/embj.2022112847 Link
Shi J, Hauschulte K, Mikicic I, Maharjan S, Arz V, Heidelberger JB, Schaefer J V, Dreier B, Plückthun A, Beli P, Ulrich HD and Wollscheid H-P (2022) Nuclear myosin VI maintains replication fork stability. Nat Commun, doi: 10.1038/s41467-023-39517-y Link
Schindler N, Tonn M, Kellner V, Fung JJ, Lockhart A, Vydzhak O, Juretschke T, Möckel S, Beli P, Khmelinskii A and Luke B (2022) Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phase. Nat Commun, doi: 10.1038/s41467-023-36866-6 Link
Lampersberger L, Conte F, Ghosh S, Xiao Y, Price J, Jordan D, Matus DQ, Sarkies P, Beli P, Miska EA and Burton NO (2023) Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function . Proc Natl Acad Sci, doi: 10.1073/pnas.2217992120 Link
2022
Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E and Eilers M (2022) MYC multimers shield stalled replication forks from RNA polymerase.Nature, doi: 10.1038/s41586-022-05469-4 Link
Oliveira CAB, Isaakova E, Beli P and Xirodimas DP (2023) A Mass Spectrometry-Based Strategy for Mapping Modification Sites for the Ubiquitin-Like Modifier NEDD8. Springer Link, doi: 10.1007/978-1-0716-2859-1_10 Link
Mosler T, Baymaz HI, Gräf JF, Mikicic I, Blattner G, Bartlett E, Ostermaier M, Piccinno R, Yang J, Voigt A, Gatti M, Pellegrino S , Altmeyer M, Luck K, Ahel I, Roukos V , Beli P (2022) PARP1 proximity reveals interaction partners at stressedreplication forksy.Nucleic Acids Re, doi: 10.1093/nar/gkac948 Link
Gräf JF, Mikicic I, Ping X, Scalera C, Mayr K, Stelzl LS, Beli P and Wagner SA (2022) Substrate spectrum of PPM1D in the cellular response to DNA double-strand breaks. iScience, doi: 10.1016/j.isci.2022.104892 Link
Winkler R, Mägdefrau A-S, Piskor E-M, Kleemann M, Beyer M, Linke K, Hansen L, Schaffer A-M, Hoffmann ME, Poepsel S, Heyd F, Beli P, Möröy T, Mahboobi S, Krämer OH and Kosan C (2022) Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition. Oncogene, doi: 10.1038/s41388-022-02450-3 Link
Wegmann S, Meister C, Renz C, Yakoub G, Wollscheid H-P, Takahashi DT, Mikicic I, Beli P and Ulrich HD (2022) Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass. Mol Cell, doi: 10.1016/j.molcel.2022.02.016 Link
Szczęśniak PP, Heidelberger JB, Serve H, Beli P and Wagner SA (2022) VCP inhibition induces an unfolded protein response and apoptosis in human acute myeloid leukemia cells. PLoS One, doi: 10.1371/journal.pone.0266478 Link
2021
Mosler T, Conte F, Longo GMC, Mikicic I, Kreim N, Möckel MM, Petrosino G, Flach J, Barau J, Luke B, Roukos V and Beli P (2021) R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nat Commun, doi: 10.1038/s41467-021-27530-y Link
Bufe A, García del Arco A, Hennecke M, de Jaime-Soguero A, Ostermaier M, Lin Y-C, Ciprianidis A, Hattemer J, Engel U, Beli P, Bastians H and Acebrón SP (2021) Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis. Proc Natl Acad Sci, doi: 10.1073/pnas.2108145118 Link
Bawankar P, Lence T, Paolantoni C, Haussmann IU, Kazlauskiene M, Jacob D, Heidelberger JB, Richter FM, Nallasivan MP, Morin V, Kreim N, Beli P, Helm M, Jinek M, Soller M and Roignant J-Y (2021) Hakai is required for stabilization of core components of the m6A mRNA methylation machinery. Nat Commun, doi: 10.1038/s41467-021-23892-5 Link
Reich TR, Schwarzenbach C, Vilar JB, Unger S, Mühlhäusler F, Nikolova T, Poplawski A, Baymaz HI, Beli P, Christmann M and Tomicic MT (2021) Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination. Cell Mol Life Sci, doi: 10.1007/s00018-021-03864-0 Link
Wagner SA, Szczesniak PP, Voigt A, Gräf JF and Beli P (2021) Proteomic analysis of tyrosine phosphorylation induced by exogenous expression of oncogenic kinase fusions identified in lung adenocarcinoma. Proteomics, doi: 10.1002/pmic.202000283 Link
Roeschert I, Poon E, Henssen AG, Dorado Garcia H, Gatti M, Giansanti C, Jamin Y, Ade CP, Gallant P, Schülein-Völk C, Beli P, Richards M, Rosenfeldt M, Altmeyer M, Anderson J, Eggert A, Dobbelstein M, Bayliss R, Chesler L, Büchel G and Eilers M (2021) Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma. Nat Cancer, doi: 10.1038/s43018-020-00171-8 Link
Juretschke T and Beli P (2021) Causes and consequences of DNA damage-induced autophagy. Matrix Biol, doi: 10.1016/j.matbio.2021.02.004 Link
Endres T, Solvie D, Heidelberger JB, Andrioletti V, Baluapuri A, Ade CP, Muhar M, Eilers U, Vos SM, Cramer P, Zuber J, Beli P, Popov N, Wolf E, Gallant P and Eilers M (2021) Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. Mol Cell, doi: 10.1016/j.molcel.2020.12.035 Link
Lobato-Gil S, Heidelberger JB, Maghames C, Bailly A, Brunello L, Rodriguez MS, Beli P and Xirodimas DP (2021) Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation. Cell Rep, doi: 10.1016/j.celrep.2020.108635 Link
2020
Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, Roedig H, Fulda S, Beli P and Wijk SJ (2020) USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination. EMBO Rep, doi: 10.15252/embr.202050163 Link
Lowe DJ, Herzog M, Mosler T, Cohen H, Felton S, Beli P, Raj K, Galanty Y and Jackson SP (2020) Chronic irradiation of human cells reduces histone levels and deregulates gene expression. Sci Rep, doi: 10.1038/s41598-020-59163-4 Link
Dold A, Han H, Liu N, Hildebrandt A, Brüggemann M, Rücklé C, Hänel H, Busch A, Beli P, Zarnack K, König J, Roignant J-Y and Lasko P (2020) Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation. PLOS Genet, doi: 10.1371/journal.pgen.1008581 Link
2019
Bekbulat F, Schmitt D, Feldmann A, Huesmann H, Eimer S, Juretschke T, Beli P, Behl C and Kern A (2019) RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations.J Mol Biol, doi: 10.1016/j.jmb.2019.12.031 Link
Hildebrandt A, Brüggemann M, Rücklé C, Boerner S, Heidelberger JB, Busch A, Hänel H, Voigt A, Möckel MM, Ebersberger S, Scholz A, Dold A, Schmid T, Ebersberger I, Roignant J-Y, Zarnack K, König J and Beli P (2019) The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.Genome Biol, doi: 10.1186/s13059-019-1814-0 Link
Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros AC, Woods M, Fu B, Yang F, Chen E, Ostermaier M, Stankovic T, Ponstingl H, Herzog M, Yusa K, Martinez FM, Durant ST, Galanty Y, Beli P, Adams DJ, Bradley A, Metzakopian E, Forment J V. and Jackson SP (2019) ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. Nat Commun, doi: 10.1038/s41467-018-07729-2 Link
Sasca D, Szybinski J, Schüler A, Shah V, Heidelberger J, Haehnel PS, Dolnik A, Kriege O, Fehr E-M, Gebhardt WH, Reid G, Scholl C, Theobald M, Bullinger L, Beli P and Kindler T (2019) Neural cell adhesion molecule 1 (NCAM1; CD56) promotes leukemogenesis and confers drug resistance in AML.Blood, doi: 10.1182/blood-2018-12-889725 Link
Juretschke T, Beli P and Dikic I (2019) Quantitative phosphoproteomics of selective autophagy receptors.Methods in Molecular Biology, doi: 10.1007/978-1-4939-8873-0_47 Link