Publications since 2019


Pradhan SK, Lozoya T, Prorok P, Yuan Y, Lehmkuhl A, Zhang P and Cardoso MC (2024) Developmental Changes in Genome Replication Progression in Pluripotent versus Differentiated Human Cells. Genes (Basel), Link

Prorok P, Wolf E and Cardoso MC (2024) Timeless–Tipin interactions with MCM and RPA mediate DNA replication stress response. Front Cell Dev Biol, doi: 10.3389/fcell.2024.1346534 Link


Pabba MK, Ritter C, Chagin VO, Meyer J, Celikay K, Stear JH, Loerke D, Kolobynina K, Prorok P, Schmid AK, Leonhardt H, Rohr K and Cardoso MC (2023) Replisome loading reduces chromatin motion independent of DNA synthesis. Elife, doi: 10.7554/eLife.87572 Link

Amiri A, Dietz C, Rapp A, Cardoso MC and Stark RW (2023) The cyto-linker and scaffolding protein “plectin” mis-localization leads to softening of cancer cells. Nanoscale, doi: 10.1039/d3nr02226a Link

Romero H, Schmidt A and Cardoso MC (2023) Protein Level Quantification Across Fluorescence-based Platforms. BIO-PROTOCOL, doi: 10.21769/BioProtoc.4834 Link

Arroyo M, Cardoso M and Hastert F (2023) In situ Quantification of Cytosine Modification Levels in Heterochromatic Domains of Cultured Mammalian Cells. BIO-PROTOCOL, doi: 10.21769/BioProtoc.4716 Link

Zhang H, Qin W, Romero H, Leonhardt H and Cardoso MC (2023) Heterochromatin organization and phase separation. Nucleus, doi: 10.1080/19491034.2022.2159142 Link


Qin W, Steinek C, Kolobynina K, Cardoso MC and Leonhardt H (2022) Probing protein ubiquitination in live cells. Nucleic Acids Res, doi: 10.1093/nar/gkac805 Link

Schmidt A, Frei J, Poetsch A, Chittka A, Zhang H, Aßmann C, Lehmkuhl A, Bauer U-M, Nuber UA and Cardoso MC (2022) MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation. Front Cell Dev Biol, doi: 10.3389/fcell.2022.941493 Link

Arroyo M, Hastert FD, Zhadan A, Schelter F, Zimbelmann S, Rausch C, Ludwig AK, Carell T and Cardoso MC (2022) Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation, doi: 10.1038/s41467-022-32799-8 Link

Kolobynina KG, Rapp A and Cardoso MC (2022) Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair. Front Cell Dev Biol, doi: 10.3389/fcell.2022.928113 Link

Mamberti S, Pabba MK, Rapp A, Cardoso MC and Scholz M (2022) The Chromatin Architectural Protein CTCF Is Critical for Cell Survival upon Irradiation-Induced DNA Damage. Int J Mol Sci, doi: 10.3390/ijms23073896 Link

Zhang H, Romero H, Schmidt A, Gagova K, Qin W, Bertulat B, Lehmkuhl A, Milden M, Eck M, Meckel T, Leonhardt H and Cardoso MC (2022) MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation. Nucleus, doi: 10.1080/19491034.2021.2024691 Link


Duan N, Arroyo M, Deng W, Cardoso MC and Leonhardt H (2021) Visualization and characterization of RNA–protein interactions in living cells. Nucleic Acids Res, doi: 10.1093/nar/gkab614 Link

Spilger R, Lee J-Y, Chagin VO, Schermelleh L, Cardoso MC, Bartenschlager R and Rohr K (2021) Deep probabilistic tracking of particles in fluorescence microscopy images. Med Image Anal, doi: 10.1016/ Link

Qin W, Ugur E, Mulholland CB, Bultmann S, Solovei I, Modic M, Smets M, Wierer M, Forné I, Imhof A, Cardoso MC and Leonhardt H (2021) Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency. Nucleic Acids Res, doi: 10.1093/nar/gkab548 Link

Rausch C, Zhang P, Casas-Delucchi CS, Daiß JL, Engel C, Coster G, Hastert FD, Weber P and Cardoso MC (2021) Cytosine base modifications regulate DNA duplex stability and metabolism. Nucleic Acids Res, doi: 10.1093/nar/gkab509 Link

Gnan S, Flyamer IM, Klein KN, Castelli E, Rapp A, Maiser A, Chen N, Weber P, Enervald E, Cardoso MC, Bickmore WA, Gilbert DM and Buonomo SCB (2021) Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction. Nat Commun, doi: 10.1038/s41467-021-22899-2 Link

Schwach J, Kolobynina K, Brandstetter K, Gerlach M, Ochtrop P, Helma J, Hackenberger CPR, Harz H, Cardoso MC, Leonhardt H and Stengl A (2021) Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy. ChemBioChem, doi: 10.1002/cbic.202000727 Link

Schneider AFL, Kithil M, Cardoso MC, Lehmann M and Hackenberger CPR (2021) Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives. Nat Chem, doi: 10.1038/s41557-021-00661-x Link

Levone BR, Lenzken SC, Antonaci M, Maiser A, Rapp A, Conte F, Reber S, Mechtersheimer J, Ronchi AE, Mühlemann O, Leonhardt H, Cardoso MC, Ruepp M-D and Barabino SML (2021) FUS-dependent liquid–liquid phase separation is important for DNA repair initiation. J Cell Biol, doi: 10.1083/jcb.202008030 Link

Qin W, Stengl A, Ugur E, Leidescher S, Ryan J, Cardoso MC and Leonhardt H (2021) HP1β carries an acidic linker domain and requires H3K9me3 for phase separation. Nucleus, doi: 10.1080/19491034.2021.1889858 Link


Rausch C, Weber P, Prorok P, Hörl D, Maiser A, Lehmkuhl A, Chagin VO, Casas-Delucchi CS, Leonhardt H and Cardoso MC (2020) Developmental differences in genome replication program and origin activation. Nucleic Acids Res, doi: 10.1093/nar/gkaa1124 Link

Cremer M, Brandstetter K, Maiser A, Rao SSP, Schmid VJ, Guirao-Ortiz M, Mitra N, Mamberti S, Klein KN, Gilbert DM, Leonhardt H, Cardoso MC, Aiden EL, Harz H and Cremer T (2020) Cohesin depleted cells rebuild functional nuclear compartments after endomitosis. Nat Commun, doi: 10.1038/s41467-020-19876-6 Link

Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert F, Angstmann N, Cardoso CM, König J, Huettelmaier S, Dieterich C, Canzar S, Helm M, Heissmeyer V, Feederle R and Meister G (2020) Validation strategies for antibodies targeting modified ribonucleotides. RNA, doi: 10.1261/rna.076026.120 Link

Mamberti S and Cardoso MC (2020) Are the processes of DNA replication and DNA repair reading a common structural chromatin unit?Nucleus, doi: 10.1080/19491034.2020.1744415 Link

Schmidt A, Zhang H and Cardoso MC (2020) MeCP2 and Chromatin Compartmentalization. Cells, doi: 10.3390/cells9040878 Link

Schneider M, Trummer C, Stengl A, Zhang P, Szwagierczak A, Cardoso MC, Leonhardt H, Bauer C and Antes I (2020) Systematic analysis of the binding behaviour of UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads. PLoS One, doi: 10.1371/journal.pone.0229144 Link

Napolitano G, Tagliaferri D, Fusco S, Cirillo C, De Martino I, Addeo M, Mazzone P, Russo NA, Natale F, Cardoso MC, De Luca L, Lamorte D, La Rocca F, De Felice M and Falco G (2020) A novel member of Prame family, Gm12794c, counteracts retinoic acid differentiation through the methyltransferase activity of PRC2. Cell Death Differ, doi: 10.1038/s41418-019-0359-9 Link



Rausch C, Hastert FD and Cardoso MC (2020) DNA Modification Readers and Writers and Their Interplay. J Mol Biol, doi: 10.1016/j.jmb.2019.12.018 Link

Chagin VO, Reinhart B, Becker A, Mortusewicz O, Jost KL, Rapp A, Leonhardt H and Cardoso MC (2019) Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair. Nucleus, doi: 10.1080/19491034.2019.1688932 Link

Heinz KS and Cardoso MC (2019) Targeted Manipulation/Repositioning of Subcellular Structures and Molecules. Doi: 10.1007/978-1-4939-9674-2_13 Link

Kasper M, Glanz M, Stengl A, Penkert M, Klenk S, Sauer T, Schumacher D, Helma J, Krause E, Cardoso MC, Leonhardt H and Hackenberger CPR (2019) Cysteine‐Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations. Angew Chemie Int Ed, doi: 10.1002/anie.201814715 Link

Zhang Y, Bertulat B, Tencer AH, Ren X, Wright GM, Black J, Cardoso MC and Kutateladze TG (2019) MORC3 Forms Nuclear Condensates through Phase Separation. iScience, doi: 10.1016/j.isci.2019.06.030 Link

Schmidt S, Schüßler M, Hessinger C, Schuster C, Bertulat B, Kithil M, Cardoso MC and Jakoby R (2019) Microwave Induced Electroporation of Adherent Mammalian Cells at 18 GHz. IEEE Access, doi: 10.1109/ACCESS.2019.2923073 Link

Zhang Y, Klein BJ, Cox KL, Bertulat B, Tencer AH, Holden MR, Wright GM, Black J, Cardoso MC, Poirier MG and Kutateladze TG (2019) Mechanism for autoinhibition and activation of the MORC3 ATPase. Proc Natl Acad Sci, doi: 10.1073/pnas.1819524116 Link

Heinz KS, Rapp A, Casas-Delucchi CS, Lehmkuhl A, Romero-Fernández I, Sánchez A, Krämer OH, Marchal JA and Cardoso MC (2019) DNA replication dynamics of vole genome and its epigenetic regulation. Epigenetics Chromatin, doi: 10.1186/s13072-019-0262-0 Link

Weber P, Rausch C, Scholl A and Cardoso MC (2019) Repli-FISH (Fluorescence in Situ Hybridization): Application of 3D-(Immuno)-FISH for the Study of DNA Replication Timing of Genetic Repeat Elements. OBM Genet, doi: 10.21926/obm.genet.1901062 Link