2022
Pan L, Tormey D, Bobon N and Baumann P (2022) Rap1 prevents fusions between long telomeres in fission yeast. EMBO J, doi: 10.15252/embj.2021110458 Link
Páez-Moscoso DJ, Ho D V., Pan L,…
In this project, we aim to systematically investigate the role of different chromatin remodelling complexes and their components in genome protection and repair, with a focus on DNA double-strand…
This project aims at clarifying mechanisms and pathways influencing DNA double-strand break repair pathway choice and at understanding how these are interlinked to cell fate choice upon DNA damage.…
Prof. Dr Karl-Peter Hopfner
Ludwig-Maximilians-University Munich Gene Center and Department of Biochemistry Feodor-Lynen-Straße 25 81377 Munich +49-(0)89-218076950 Email
Webpage Hopfner…
Thomas Hofmann: Dissecting the mechanism underlying repair versus cell death pathway choice upon DNA damage (Project 19, 2019-2022)
The protein kinase HIPK2 is activated by DNA damage signalling and…
Karl-Peter Hopfner: Structural mechanism of MRN-ATM in DSB signalling and processing (Project 18, 2019-2022)
The MRN complex is a multifunctional nuclease that initiates DNA double-strand break…
2023
Zhang K, Da Silva F, Seidl C, Wilsch-Bräuninger M, Herbst J, Huttner WB and Niehrs C (2023) Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis. Dev…
2022
Rotheneder M, Stakyte K, van de Logt E, Bartho JD, Lammens K, Fan Y, Alt A, Kessler B, Jung C, Roos WP, Steigenberger B and Hopfner K-P (2022) Cryo-EM structure of the Mre11-Rad50-Nbs1 complex…
