Publications since 2019

2023

González A and Dikić I (2023) Decoding Golgiphagy: selective recycling under stress. Cell Res, doi: 10.1038/s41422-023-00905-0 Link

Mende H, Khatri A, Lange C, Poveda-Cuevas SA, Tascher G, Covarrubias-Pinto A, Löhr F, Koschade SE, Dikic I, Münch C, Bremm A, Brunetti L, Brandts CH, Uckelmann H, Dötsch V, Rogov V V., Bhaskara RM and Müller S (2023) An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant. Cell Rep, doi: 10.1016/j.celrep.2023.113484 Link

Patil PR, Burroughs AM, Misra M, Cerullo F, Costas-Insua C, Hung H-C, Dikic I, Aravind L and Joazeiro CAP (2023) Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10. Cell Rep, doi: 10.1016/j.celrep.2023.113100 Link

Mello-Vieira J, Bopp T and Dikic I (2023) Ubiquitination and cell-autonomous immunity. Curr Opin Immunol, doi: 10.1016/j.coi.2023.102368 Link

Schierwagen R, Gu W, Brieger A, Brüne B, Ciesek S, Đikić I, Dimmeler S, Geisslinger G, Greten FR, Hermann E, Hildt E, Kempf VAJ, Klein S, Koch I, Mühl H, Müller V, Peiffer K-H, Kestner R-I, Piiper A, Rohde G, Scholich K, Schulz MH, Storf H, Toptan T, Vasa-Nicotera M, Vehreschild MJGT, Weigert A, Wild PJ, Zeuzem S, Engelmann C, Schaefer L, Welsch C and Trebicka J (2023) Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure. Am J Physiol Physiol, doi: 10.1152/ajpcell.00101.2023 Link

Pérez Berrocal DA, Vishwanatha TM, Horn‐Ghetko D, Botsch JJ, Hehl LA, Kostrhon S, Misra M, Ðikić I, Geurink PP, van Dam H, Schulman BA and Mulder MPC (2023) A Pro‐Fluorescent Ubiquitin‐Based Probe to Monitor Cysteine‐Based E3 Ligase Activity. Angew Chemie Int Ed, doi: 10.1002/anie.202303319 Link

González A, Covarrubias-Pinto A, Bhaskara R, Glogger M, Kuncha S, Xavier A, Seemann E, Misra M, Hoffmann M, Bräuning B, Balakrishnan A, Qualmann B, Dötsch V, Schulman B, Kessels M, Hubner C, Heilemann M, Hummer G and Dikic I (2023) Ubiquitination regulates ER-phagy and remodelling of the endoplasmic reticulum. Nature, doi: 10.1038/s41586-023-06089-2 Link

Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, González A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Dikić I and Hübner CA (2023) Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy.Nature, doi: 10.1038/s41586-023-06090-9 Link

Lamond AI, Dikic I, Nussenzweig A, Müller CW, Thornton JM and Yaffe MB (2023) The mission to ensure continued funding for excellent basic research. EMBO Rep, doi: 10.15252/embr.202357498 Link

Bhattacharya A, Mukherjee R, Kuncha SK, Brunstein ME, Rathore R, Junek S, Münch C and Dikic I (2023) A lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins. Nat Cell Biol, doi: 10.1038/s41556-023-01125-9 Link

Karantanou C, Minciacchi VR, Kumar R, Zanetti C, Bravo J, Pereira RS, Tascher G, Tertel T, Covarrubias-Pinto A, Bankov K, Pfeffermann L-M, Bonig H, Divieti-Pajevic P, McEwan DG, Giebel B, Münch C, Dikic I and Krause DS (2023) Impact of mesenchymal stromal cell–derived vesicular cargo on B-cell acute lymphoblastic leukemia progression. Blood Adv, doi: 10.1182/bloodadvances.2022007528 Link

Dikic I and Schulman BA (2023) An expanded lexicon for the ubiquitin code. Nat Rev Mol Cell Biol, doi: 10.1038/s41580-022-00543-1 Link

2022

Krause DS and Dikic I (2022) Mycobacterium tuberculosis hijacks ubiquitin to inhibit pyroptosis. Mol Cell, doi: 10.1016/j.molcel.2022.11.020 Link

Hertel A, Alves LM, Dutz H, Tascher G, Bonn F, Kaulich M, Dikic I, Eimer S, Steinberg F and Bremm A (2022) USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Cell Rep, doi: 10.1016/j.celrep.2022.111653 Link

Merline R, Rödig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M and Schaefer L (2022) A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1) - a novel modulator of mitochondrial autophagy. Am J Physiol Physiol, doi: 10.1152/ajpcell.00493.2022 Link

Oo JA, Pálfi K, Warwick T, Wittig I, Prieto-Garcia C, Matkovic V, Tomašković I, Boos F, Izquierdo Ponce J, Teichmann T, Petriukov K, Haydar S, Maegdefessel L, Wu Z, Pham MD, Krishnan J, Baker AH, Günther S, Ulrich HD, Dikic I, Leisegang MS and Brandes RP (2022) Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. Cell Rep, doi: 10.1016/j.celrep.2022.111670 Link

Voorneveld J, Kloet MS, Wijngaarden S, Kim RQ, Moutsiopoulou A, Verdegaal M, Misra M, Đikić I, van der Marel GA, Overkleeft HS, Filippov D V. and van der Heden van Noort GJ (2022) Arginine ADP-Ribosylation: Chemical Synthesis of Post-Translationally Modified Ubiquitin Proteins. J Am Chem Soc, doi: 10.1021/jacs.2c06249 Link

Shah VJ and Đikić I (2022) Localization matters in targeted protein degradation. Cell Chem Biol, doi: 10.1016/j.chembiol.2022.09.006 Link

Karantanou C, Minciacchi VR, Kumar R, Zanetti C, Bravo J, S. Pereira R, Tascher G, Tertel T, Covarrubias-Pinto A, Bankov K, Pfeffermann L-M, Bonig H, Divieti-Pajevic P, McEwan DG, Giebel B, Münch C, Dikic I and Krause DS (2022) Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression. Blood Adv, doi: 10.1182/bloodadvances.2022007528 Link

Amstein LK, Ackermann J, Hannig J, Đikić I, Fulda S and Koch I (2022) Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways applying Petri net formalism and in silico knockout analysis. PLOS Comput Biol, doi: 10.1371/journal.pcbi.1010383 Link

Tiku V, Kew C, Kofoed EM, Peng Y, Dikic I and Tan M-W (2022) Acinetobacter baumannii Secretes a Bioactive Lipid That Triggers Inflammatory Signaling and Cell Death. Front Microbiol, doi: 10.3389/fmicb.2022.870101 Link

Gubas A and Dikic I (2022) ER remodeling via ER-phagy. Mol Cell, doi: 10.1016/j.molcel.2022.02.018 Link

Prieto‐Garcia C, Hartmann O, Reissland M, Braun F, Bozkurt S, Pahor N, Fuss C, Schirbel A, Schülein‐Völk C, Buchberger A, Calzado Canale MA, Rosenfeldt M, Dikic I, Münch C and Diefenbacher ME (2022) USP28 enables oncogenic transformation of respiratory cells and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.Mol Oncol, dio: 10.1002/1878-0261.13217 Link

Tomaskovic I, Gonzalez A and Dikic I (2022) Ubiquitin and Legionella: From bench to bedside. Semin Cell Dev Biol, doi: 10.1016/j.semcdb.2022.02.008 LinkTomaskovic I, Gonzalez A and Dikic I (2022) Ubiquitin and Legionella: From bench to bedside. Semin Cell Dev Biol, doi: 10.1016/j.semcdb.2022.02.008 Link

Cable J, Weber‐Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, Chang C, Ge L, Schulman BA, Deshaies RJ, Dikic I, Harper JW, Wertz IE, Thomä NH, Słabicki M, Frydman J, Jakob U, David DC, Bennett EJ, Bertozzi CR, Sardana R, Eapen V V. and Carra S (2022) Targeted protein degradation: from small molecules to complex organelles—a Keystone Symposia report. Ann N Y Acad Sci, doi: 10.1111/nyas.14745 Link

 

2021

Zhou J, Dabiri Y, Gama-Brambila RA, Ghafoory S, Altinbay M, Mehrabi A, Golriz M, Blagojevic B, Reuter S, Han K, Seidel A, Đikić I, Wölfl S and Cheng X (2022) pVHL-mediated SMAD3 degradation suppresses TGF-β signaling. J Cell Biol, doi: 10.1083/jcb.202012097 Link

Prieto-Garcia C, Hartmann O, Reissland M, Fischer T, Maier CR, Rosenfeldt M, Schülein-Völk C, Klann K, Kalb R, Dikic I, Münch C and Diefenbacher ME (2021) Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. Cell Death Differ, doi: 10.1038/s41418-021-00875-z Link

Schünke H, Göbel U, Dikic I and Pasparakis M (2021) OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun, doi: 10.1038/s41467-021-25945-1 Link

Prieto-Garcia C, Tomašković I, Shah VJ, Dikic I and Diefenbacher M (2021) USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma. Cells, doi: 10.3390/cells10102652 Link

Mukherjee R, Bhattacharya A, Bojkova D, Mehdipour AR, Shin D, Khan KS, Hei-Yin Cheung H, Wong K-B, Ng W-L, Cinatl J, Geurink PP, van der Heden van Noort GJ, Rajalingam K, Ciesek S, Hummer G and Dikic I (2021) Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection. J Biol Chem, doi: 10.1016/j.jbc.2021.100925 Link

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo‐San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen E, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez‐Otin C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon H, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L and Pietrocola F (2021) Autophagy in major human diseases. EMBO J, doi: 10.15252/embj.2021108863 Link

Maculins T and Dikic I (2021) Gasdermin B in the host–pathogen tug-of-war. Cell Res, doi: 10.1038/s41422-021-00544-3 Link

Gerstmeier J, Possmayer A-L, Bozkurt S, Hoffmann ME, Dikic I, Herold-Mende C, Burger MC, Münch C, Kögel D and Linder B (2021) Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide. Cancers (Basel), doi: 10.3390/cancers13143577 Link

Valečka J, Camosseto V, McEwan DG, Terawaki S, Liu Z, Strock E, Almeida CR, Su B, Dikic I, Liang Y, Gatti E and Pierre P (2021) RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages. R Soc Open Sci, doi: 10.1098/rsos.202333 Link

Liu Y, Mukherjee R, Bonn F, Colby T, Matic I, Glogger M, Heilemann M and Dikic I (2021) Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection. Cell Death Differ, doi: 10.1038/s41418-021-00830-y Link

Armstrong LA, Lange SM, Dee Cesare V, Matthews SP, Nirujogi RS, Cole I, Hope A, Cunningham F, Toth R, Mukherjee R, Bojkova D, Gruber F, Gray D, Wyatt PG, Cinatl J, Dikic I, Davies P and Kulathu Y (2021) Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. PLoS One, doi: 10.1371/journal.pone.0253364 Link

Schaefer L and Dikic I (2021) Autophagy: Instructions from the extracellular matrix. Matrix Biol, doi: 10.1016/j.matbio.2021.06.002 Link

Mukherjee R, Bhattacharya A, Bojkova D, Mehdipour AR, Shin D, Khan KS, Hei-Yin Cheung H, Wong K-B, Ng W, Cinatl J, Geurink PP, van der Heden van Noort GJ, Rajalingam K, Ciesek S, Hummer G and Dikic I (2021) Famotidine inhibits Toll-like receptor 3-mediated inflammatory signaling in SARS-CoV2 infection. J Biol Chem, doi: 10.1016/j.jbc.2021.100925 Link

Linder B, Klein C, Hoffmann ME, Bonn F, Dikic I and Kögel D (2021) BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple‐negative breast cancer cells. J Cell Biochem, doi: 10.1002/jcb.30073 Link

Maculins T, Verschueren E, Hinkle T, Choi M, Chang P, Chalouni C, Rao S, Kwon Y, Lim J, Katakam AK, Kunz RC, Erickson BK, Huang T, Tsai T-H, Vitek O, Reichelt M, Senbabaoglu Y, Mckenzie B, Rohde JR, Dikic I, Kirkpatrick DS and Murthy A (2021) Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response. Elife, doi: 10.7554/eLife.62320 Link

Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Müller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I and Kaulich M (2021) Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic Acids Res, doi: 10.1093/nar/gkab309 Link

Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Münch C, Rajalingam K, Randow F, Choudhary C and Dikic I (2021) SIK2 orchestrates actin-dependent host response upon Salmonella infection. Proc Natl Acad Sci, doi: 10.1073/pnas.2024144118 Link

Lo HS, Hui KPY, Lai H-M, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH-Y, Ng K-C, Ho JCW, Chen YW, Ma B, Cheung PM-H, Shin D, Wang K, Lee M-H, Selisko B, Eydoux C, Guillemot J-C, Canard B, Wu K-P, Liang P-H, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong K-B, Mok CKP, Ko H, Aik WS, Chan MCW and Ng W-L (2021) Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir. ACS Cent Sci, doi: 10.1021/acscentsci.0c01186 Link

Kannt A and Đikić I (2021) Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation. Cell Chem Biol, doi: 10.1016/j.chembiol.2021.04.007 Link

Gubas A and Dikic I (2021) A Guide To… The Regulation Of Selective Autophagy Receptors. FEBS J, doi: 10.1111/febs.15824 Link

Klionsky DJ et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 8:1-382 Link

Gubas A, Karantanou C, Popovic D, Tascher G, Hoffmann ME, Platzek A, Dawe N, Dikic I, Krause DS and McEwan D. (2021) The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways. FEBS Lett, doi: 10.1002/1873-3468.14041 Link

Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I and Tan M-W (2021) Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii. Sci Rep, doi: 10.1038/s41598-020-79966-9 Link

Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, Vilar S, Wang J, Zuercher WJ, Willson TM and Drewry DH (2021) The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. Int J Mol Sci, doi: 10.3390/ijms22020566 Link

2020

Shin D, Bhattacharya A, Cheng Y-L, Alonso MC, Mehdipour AR, van der Heden van Noort GJ, Ovaa H, Hummer G and Dikic I (2020) Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. Elife, doi: 10.7554/eLife.58277 Link

van der Heden van Noort G, Kim RQ, Misra M, Alexis G, Tomašković I, Shin D, Schindelin H, Filippov D V., Ovaa H and Dikic I (2020) Development of ADPribosyl ubiquitin analogs to study enzymes involved in Legionella infection. Chem – A Eur J, doi: 10.1002/chem.202004590 Link

Waidmann O, Pleli T, Weigert A, Imelmann E, Kakoschky B, Schmithals C, Döring C, Frank M, Longerich T, Köberle V, Hansmann M-L, Brüne B, Zeuzem S, Piiper A and Dikic I (2020) Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis. Sci Rep, doi: 10.1038/s41598-020-73387-4 Link

CA, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P and Settembre C (2020) MiT/TFE factors control ER ‐phagy via transcriptional regulation of FAM134B. EMBO J, doi: 10.15252/embj.2020105696 Link

Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M and Dikic I (2020) Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. Cell Chem Biol, doi: 10.1016/j.chembiol.2020.07.010 Link

Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch K-P, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S and Dikic I (2020) Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature, doi: 10.1038/s41586-020-2601-5 Link

van der Heden van Noort G, Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codee JDC and Filippov D V. (2020) Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitinating Enzyme SdeC. ChemBioChem, doi: 10.1002/cbic.202000230 Link

Putyrski M, Vakhrusheva O, Bonn F, Guntur S, Vorobyov A, Brandts C, Dikic I and Ernst A (2020) Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine. Front Cell Dev Biol, doi: 10.3389/fcell.2020.00208 Link

Tiku V, Tan M-W and Dikic I (2020) Mitochondrial Functions in Infection and Immunity.Trends Cell Biol, doi: 10.1016/j.tcb.2020.01.006 Link

Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J and Dikic I (2020) Wss1 Promotes Replication Stress Tolerance by Degrading Histones.Cell Rep, doi: 10.1016/j.celrep.2020.02.018 Link

Hübner CA and Dikic I (2020) ER-phagy and human diseases. Cell Death Differ, doi: 10.1038/s41418-019-0444-0 Link

Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, Widera D, Fulda S, Wajant H, van Wijk SJL, Dikic I and Heilemann M (2020) Single-molecule imaging reveals the oligomeric state of functional TNFa-induced plasma membrane TNFR1 clusters in cells.Sci Signal, doi: 10.1126/scisignal.aax5647 Link

2019

Pohl C and Dikic I (2019) Cellular quality control by the ubiquitin-proteasome system and autophagy.Science, doi: 10.1126/science.aax3769 Link

Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, Simonsen A, Hummer G and Dikic I (2019) TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease. EMBO Rep, doi: 10.15252/embr.201948317 Link

Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov V V., Heinz M, Stolz A, Hummer G, Dötsch V, Luo Z-Q, Bhogaraju S and Dikic I (2019) Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Mol Cell, doi: 10.1016/j.molcel.2019.10.019 Link

Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D and Dikic I (2019) Inhibition of bacterial ubiquitin ligases by SidJ–calmodulin-catalysed glutamylation. Nature, doi: 10.1038/s41586-019-1440-8Link

Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M and Settembre C (2019) A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex. EMBO J, doi: 10.15252/embj.201899847 Link

Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V and Rogov V V. (2019) An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.Autophagy, doi: 10.1080/15548627.2019.1606637 Link

Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V and Kögel D (2019) Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling.Cancers (Basel), doi: 10.3390/cancers11030350 Link

Tiku V and Dikic I (2019) Autophagy without conjugation.Nat Struct Mol Biol, doi: 10.1038/s41594-019-0207-0 Link

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LTH, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo R V., Wygrecka M and Schaefer L (2019) Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.Kidney Int, doi: 10.1016/j.kint.2018.10.037 Link

Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A and Kaulich M (2019) Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Elife, doi: 10.7554/eLife.42549 Link

Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I and Hummer G (2019) Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy.Nat Commun, doi: 10.1038/s41467-019-10345-3 Link

Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I and Potente M (2019) Deubiquitinase USP10 regulates notch signaling in the endothelium. Science, doi: 10.1126/science.aat0778 Link

Nguyen D, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I and Brandts CH (2019) Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy.Blood, doi: 10.1182/blood-2018-02-833475 Link

Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I and Rahighi S (2019) Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains. J Mol Biol, doi: 10.1016/j.jmb.2019.06.012 Link

Mukherjee R and Dikic I (2019) NIPSNAP Beacons in Mitophagy. Dev Cell, doi: 10.1016/j.devcel.2019.05.008 Link

Juretschke T, Beli P and Dikic I (2019) Quantitative phosphoproteomics of selective autophagy receptors.Methods in Molecular Biology, doi: 10.1007/978-1-4939-8873-0_46 Link

van Wijk SJ, Fulda S, Dikic I and Heilemann M (2019) Visualizing ubiquitination in mammalian cells.EMBO Rep, doi: 10.15252/embr.201846520 Link